Every cell has an engine.
Mitochondria turn food into the energy that keeps each cell running and repairing itself.
02 — Research
Three bets on renewal.
Each program targets a different layer of cellular aging. Scroll to watch a mitochondrion lose its power and get it back.
The lights dim.
With age the engine sputters: less energy, more waste, and repairs fall behind.
We refuel it.
Programs like ANX-03 are designed to restore the molecules mitochondria run on.
Power returns.
A charged cell can clean up, repair and divide like a young one again.
Scroll to play
Programs
Scroll through
the pipeline.
ANX-01 · Preclinical
Clear the stuck cells.
An oral small-molecule combination designed to remove senescent cells selectively, given in short, spaced-out courses rather than every day.
- Layer
- Senescence
- Format
- Oral capsule
- Model
- Aged fibroblasts
- Next step
- In vivo study
ANX-02 · Discovery
Reset the switches.
Brief, controlled expression of reprogramming factors delivered by lipid nanoparticles, aiming to restore younger gene-regulation patterns while keeping cell identity intact.
- Layer
- Epigenetics
- Format
- mRNA in LNPs
- Model
- Human skin cells
- Next step
- Dose finding
ANX-03 · Preclinical
Refuel the engine.
A pairing of an NAD⁺ precursor with a compound that helps cells recycle damaged mitochondria, to bring energy production back up.
- Layer
- Mitochondria
- Format
- Oral combination
- Model
- Worms & mice
- Next step
- Formulation
Where each program stands
Honest progress.
DiscoveryPreclinicalIND-enablingPhase I
ANX-01Senolytic
ANX-02Epigenetic reset
ANX-03Mito-renewal
Platform
The tools behind the work.
Screening
Aged cell lines grown in-house let us test many candidates side by side, quickly and cheaply.
Age read-outs
Imaging plus our clock model tells us whether a treated cell looks biologically younger.
Delivery
We design our own lipid nanoparticles so payloads reach the right cells at the right dose.
Lab notes
What we've shared.
2026 · Note
A faster read-out for biological age in cultured cells
Preprint · in prep2026 · Poster
Spaced dosing of a senolytic combination in aged fibroblasts
Student symposium2025 · Note
Mitochondrial recycling as a lever on cellular energy
Lab blog2025 · Talk
